Op een congres van de Wikipedia)is onderzoek gepresenteerd dat laat zien dat Alzheimer eerder optreed bij mensen die roken of alcohol gebruiken. De combinatie van roken en alcohol geeft meer risiko dan de twee afzonderlijk. ( /
Heavy drinking and smoking is associated with a significantly earlier age of development of late-onset Alzheimerâ€™s disease, according to findings presented April 16 at the annual meeting of the American Academy of Neurology.
In a retrospective analysis of 686 patients diagnosed with possible or probable Alzheimerâ€™s disease, people who were heavy drinkers, defined as having more than two drinks of wine, beer, or spirits per day, developed Alzheimerâ€™s 5 years earlier than those who were not drinkers (onset 71 vs. 76 years).
People who smoked at least a pack of cigarettes per day developed the disease 2 years sooner than nonsmokers (73 vs. 75 years).
The combination of heavy drinking and smoking reduced the age at onset by 6 to 7 years, compared with those who did not drink or smoke heavily, lead investigator Dr. Ranjan Duara, medical director of the Wien Center for Alzheimerâ€™s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, and associates reported in a poster.
Genetic testing revealed that 27% of patients were positive for the apolipoprotein-epsilon (APOE) 4 allele, which has long been considered a risk factor for Alzheimerâ€™s. Patients with APOE-epsilon4 developed the disease 3 years sooner than those without the gene variant. Gender had no significant influence on age of onset.
â€œThese may be potentially important public health measures to reduce the prevalence of Alzheimerâ€™s disease, especially among those with increased genetic risk,â€ Dr. Duara said during a press briefing at the meeting.