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Tight glucose control among ICU patients significantly raised the risk of death within 90 days, compared with conventional glucose control, Dr. Simon Finfer reported at the International Symposium on Intensive Care and Emergency Medicine in Brussels.
In a large, international, randomized clinical trial, a blood glucose target of less than 180 mg/dL resulted in lower mortality than a target of 81-108 mg/dL. â€œOn the basis of these results, we do not recommend use of the lower target in critically ill adults,â€ Dr. Finfer said.
The study will appear in the March 26 issue of the New England Journal of Medicine, and the article was released online in concert with Dr. Finferâ€™s presentation at the symposium (N. Engl. J. Med. 2009 March 24 [doi:10.1056/NEJMoa0810625]).
The 90-day mortality was 24.9% with conventional glucose control and 27.5% with tight glucose control, a significant difference. â€œThis represents a number needed to harm of 38,â€ Dr. Finfer said (N. Engl. J. Med. 2009;360:1283-97).